Secreted type of amyloid precursor protein induces glial differentiation by stimulating the BMP/Smad signaling pathway.

@article{Kwak2014SecretedTO,
  title={Secreted type of amyloid precursor protein induces glial differentiation by stimulating the BMP/Smad signaling pathway.},
  author={Young-Don Kwak and Brandon J Hendrix and Kiminobu Sugaya},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={447 3},
  pages={394-9}
}
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases leading to dementia. Although cytotoxicity of amyloid β peptides has been intensively studied within pathophysiology of AD, the physiological function of amyloid precursor protein (APP) still remains unclarified. We have shown previously that secreted APPα (sAPPα) is associated… CONTINUE READING