Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.

Abstract

Hematopoietic stem cells (HSCs) remain mostly quiescent under steady-state conditions but switch to a proliferative state following hematopoietic stress, e.g., bone marrow (BM) injury, transplantation, or systemic infection and inflammation. The homeostatic balance between quiescence, self-renewal, and differentiation of HSCs is strongly dependent on their… (More)
DOI: 10.1172/JCI92571

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