Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells.

@article{Kim2010SecretedP1,
  title={Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells.},
  author={Jinyoung Kim and David W. Erikson and Robert C. Burghardt and Thomas E Spencer and Guoyao Wu and Kayla J. Bayless and Gregory A. Johnson and Fuller W Bazer},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2010},
  volume={29 5},
  pages={369-82}
}
Attachment and migration of trophectoderm (Tr) cells, hallmarks of blastocyst implantation in mammals, are unique uterine events. Secreted phosphoprotein 1 (SPP1) in the uterus binds integrins on conceptus Tr and uterine luminal epithelium (LE), affecting cell-cell and cell-matrix interactions. The signal transduction pathways activated by SPP1 and integrins in conceptuses have not been elucidated. Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce… CONTINUE READING

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