Secreted phospholipase A(2) induces vascular endothelial cell migration.

@article{Rizzo2000SecretedPA,
  title={Secreted phospholipase A(2) induces vascular endothelial cell migration.},
  author={Mar{\'i}a Teresa Palominos Rizzo and Eric Nguyen and Marlene A. Aldo-Benson and G{\'e}rard Lambeau},
  journal={Blood},
  year={2000},
  volume={96 12},
  pages={
          3809-15
        }
}
Secreted phospholipase A(2) (sPLA(2)) regulates a variety of cellular functions. The present investigation was undertaken to elucidate the potential role of sPLA(2) in endothelial cell (EC) migration. Bovine aortic endothelial cells (BAECs) exposed to sPLA(2) placed in the lower compartment of a modified Boyden chamber displayed increased migration compared to cells exposed to vehicle. The effect of sPLA(2) on EC migration was time and dose dependent. Migration of BAECs was observed at 30… CONTINUE READING

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