Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3.

@article{Luo2010SecretedPA,
  title={Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3.},
  author={Shanshan Luo and Andrea Hartmann and H. M. Dahse and Christine Skerka and Peter F Zipfel},
  journal={Journal of immunology},
  year={2010},
  volume={185 4},
  pages={2164-73}
}
The complement system forms the first defense line of innate immunity and is activated within seconds upon infection by human pathogenic yeast Candida albicans. In this study, we identified a new complement evasion strategy used by C. albicans. The fungus secretes a potent complement inhibitor, pH-regulated Ag 1 (Pra1), which in the direct surrounding of the pathogen binds to fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, as shown by ELISA, native gel electrophoresis, and Western… CONTINUE READING

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