Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm

@article{Smith1993SecretedNP,
  title={Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm},
  author={William C Smith and Anne K. Knecht and Mike Wu and Richard M Harland},
  journal={Nature},
  year={1993},
  volume={361},
  pages={547-549}
}
ADORSALIZING signal acts during gastrulation to change the specification of lateral mesodermal tissues from ventral (blood, mesenchyme) to more dorsal fates (muscle, heart, pronephros)1–3. This signal, from Spemann's organizer, cannot be mimicked by the mesoderm inducers activin and fibroblast growth factor2. The gene noggin is expressed in the organizer4… CONTINUE READING