Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis.

@article{Park2012SecretedHG,
  title={Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis.},
  author={Min Chul Park and Taehee Kang and Da Peng Jin and Jung Min Han and Sang Bum Kim and Yun Jung Park and Kiwon Cho and Young Woo Park and Min Guo and Weiwei He and Xiang-Lei Yang and Paul R. Schimmel and Sunghoon Kim},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 11},
  pages={E640-7}
}
Although adaptive systems of immunity against tumor initiation and destruction are well investigated, less understood is the role, if any, of endogenous factors that have conventional functions. Here we show that glycyl-tRNA synthetase (GRS), an essential component of the translation apparatus, circulates in serum and can be secreted from macrophages in… CONTINUE READING