Secreted heat shock protein-90 (Hsp90) in wound healing and cancer.

  title={Secreted heat shock protein-90 (Hsp90) in wound healing and cancer.},
  author={Wei W. Li and Divya Bala Sahu and Fred Tsen},
  journal={Biochimica et biophysica acta},
  volume={1823 3},
Extracellular Hsp90 proteins, including "membrane-bound", "released" and "secreted", were first reported more than two decades ago. Only studies of the past 7years have begun to reveal a picture for when, how and why Hsp90 gets exported by both normal and tumor cells. Normal cells secrete Hsp90 in response to tissue injury. Tumor cells have managed to constitutively secrete Hsp90 for tissue invasion. In either case, sufficient supply of the extracellular Hsp90 can be guaranteed by its unusually… CONTINUE READING


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