Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition.

Abstract

BACKGROUND The long held view is that mammalian cells obtain transferrin (Tf) bound iron utilizing specialized membrane anchored receptors. Here we report that, during increased iron demand, cells secrete the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) which enhances cellular uptake of Tf and iron. METHODS These observations could… (More)
DOI: 10.1016/j.bbagen.2013.03.019

Topics

Statistics

0102030201520162017
Citations per Year

Citation Velocity: 5

Averaging 5 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.

Cite this paper

@article{Sheokand2013SecretedGD, title={Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition.}, author={Navdeep Sheokand and Santosh Kumar and Himanshu Malhotra and Vikas Ajit Tillu and Chaaya Iyengar Raje and Manoj Raje}, journal={Biochimica et biophysica acta}, year={2013}, volume={1830 6}, pages={3816-27} }