Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition.

@article{Mori2012SecretedFP,
  title={Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition.},
  author={Hiroyuki Mori and Tyler Carl Prestwich and Michael Austin Ross Reid and Kenneth A. Longo and Isabelle Gerin and William P Cawthorn and Vedrana S. Susulic and Venkatesh Krishnan and Andy Greenfield and Ormond A Macdougald},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 7},
  pages={
          2405-16
        }
}
Preadipocytes secrete several WNT family proteins that act through autocrine/paracrine mechanisms to inhibit adipogenesis. The activity of WNT ligands is often decreased by secreted frizzled-related proteins (SFRPs). Sfrp5 is strongly induced during adipocyte differentiation and increases in adipocytes during obesity, presumably to counteract WNT signaling. We tested the hypothesis that obesity-induced Sfrp5 expression promotes the development of new adipocytes by inhibiting endogenous… CONTINUE READING
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