Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer.

@article{Horvath2007SecretedFP,
  title={Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer.},
  author={Lisa G. Horvath and Jayne E Lelliott and James G Kench and C V Lee and Elizabeth D. Williams and Darren N Saunders and John J. Grygiel and Robert Lyndsay Sutherland and Susan M. Henshall},
  journal={The Prostate},
  year={2007},
  volume={67 10},
  pages={
          1081-90
        }
}
BACKGROUND Secreted frizzled-related proteins (sFRP4) inhibits Wnt signaling and thus cellular proliferation in androgen-independent prostate cancer cells in vitro. However, increased expression of membranous sFRP4 is associated with a good prognosis in human localized androgen-dependent prostate cancer, suggesting a role for sFRP4 in early stage disease. Here, we investigated the phenotype of sFRP4 overexpression in an androgen-dependent prostate cancer model. METHODS An sFRP4-overexpressing… CONTINUE READING
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