Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor.

@article{SantiagoGarca2001SecretedFO,
  title={Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor.},
  author={Juan Santiago-Garc{\'i}a and Jaime Mas-Oliva and Thomas L. Innerarity and Robert E. Pitas},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 33},
  pages={
          30655-61
        }
}
Upon activation, platelets secrete a 120-kDa protein that competes for the binding and internalization of acetyl low density lipoproteins (AcLDL) by macrophages. From the amino-terminal amino acid sequence, amino acid composition, and immunoblot analysis, we identified the active factor in platelet secretion products as sAPP, an alpha-secretase cleavage product of the beta-amyloid precursor protein (APP), that contains a Kunitz-type protease inhibitor (KPI) domain. We showed that both sAPP751… CONTINUE READING
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