Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury.

@article{SmithSwintosky1994SecretedFO,
  title={Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury.},
  author={Virginia L. Smith-Swintosky and Luther Creed Pettigrew and Susan D Craddock and A R Culwell and Russell E. Rydel and Mark P. Mattson},
  journal={Journal of neurochemistry},
  year={1994},
  volume={63 2},
  pages={781-4}
}
The beta-amyloid precursor protein (beta APP) is the source of the amyloid beta-peptide that accumulates in the brain in Alzheimer's disease. A major processing pathway for beta APP involves an enzymatic cleavage within the amyloid beta-peptide sequence that liberates secreted forms of beta APP (APPss) into the extracellular milieu. We now report that postischemic administration of these APPss intracerebroventricularly protects neurons in the CA1 region of rat hippocampus against ischemic… CONTINUE READING

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