Secreted amyloid precursor protein and holo-APP bind amyloid beta through distinct domains eliciting different toxic responses on hippocampal neurons.

@article{Kedikian2010SecretedAP,
  title={Secreted amyloid precursor protein and holo-APP bind amyloid beta through distinct domains eliciting different toxic responses on hippocampal neurons.},
  author={Gabriela Kedikian and Florencia Heredia and Victoria Roz{\'e}s Salvador and Daniel Raimunda and Nora A. Isoardi and Lorena Heredia and Alfredo J. Mart{\'i}nez Lorenzo},
  journal={Journal of neuroscience research},
  year={2010},
  volume={88 8},
  pages={
          1795-803
        }
}
Amyloid beta (Abeta) is a metabolic product of Abeta precursor protein (APP). Deposition of Abeta in the brain and neuronal degeneration are characteristic hallmarks of Alzheimer's disease (AD). Abeta induces neuronal degeneration, but the mechanism of neurotoxicity remains elusive. Increasing evidence implicates APP as a receptor-like protein for Abeta fibrils (fAbeta). In this study, we present further experimental support for the direct interaction of APP with fAbeta and for its involvement… CONTINUE READING

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