Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development


Mice lacking secreted IgM (sIgM −/−) antibodies display abnormal splenic B cell development, which results in increased marginal zone and decreased follicular B cell numbers. However, the mechanism by which sIgM exhibit this effect is unknown. Here, we demonstrate that B cells in sIgM −/− mice display increased B cell receptor (BCR) signaling as judged by… (More)
DOI: 10.1038/s41598-017-03688-8

4 Figures and Tables


  • Presentations referencing similar topics