Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development

Abstract

Mice lacking secreted IgM (sIgM −/−) antibodies display abnormal splenic B cell development, which results in increased marginal zone and decreased follicular B cell numbers. However, the mechanism by which sIgM exhibit this effect is unknown. Here, we demonstrate that B cells in sIgM −/− mice display increased B cell receptor (BCR) signaling as judged by… (More)
DOI: 10.1038/s41598-017-03688-8

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