Secreted Bacillus anthracis proteases target the host fibrinolytic system.

  title={Secreted Bacillus anthracis proteases target the host fibrinolytic system.},
  author={M C Chung and Shelley C Jorgensen and Jessica H. Tonry and Fatah Kashanchi and Charles L. Bailey and Serguei G. Popov},
  journal={FEMS immunology and medical microbiology},
  volume={62 2},
The fibrinolytic system is often the target for pathogenic bacteria, resulting in increased fibrinolysis, bacterial dissemination, and inflammation. The purpose of this study was to explore whether proteases NprB and InhA secreted by Bacillus anthracis could activate the host's fibrinolytic system. NprB efficiently activated human pro-urokinase plasminogen activator (pro-uPA), a key protein in the fibrinolytic cascade. Conversely, InhA had little effect on pro-uPA. Plasminogen activator… CONTINUE READING


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Bacillus anthracis

  • DV Mukherjee, JH Tonry, +5 authors MC Chung
  • 2011
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