Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

@article{YoungPearse2008SecretedAR,
  title={Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1},
  author={Tracy L Young-Pearse and Allen C. Chen and Rui B. Chang and Cesar Marquez and Dennis J Selkoe},
  journal={Neural Development},
  year={2008},
  volume={3},
  pages={15 - 15}
}
β-Amyloid precursor protein (APP) has been reported to play a role in the outgrowth of neurites from cultured neurons. Both cell-surface APP and its soluble, ectodomain cleavage product (APPs-α) have been implicated in regulating the length and branching of neurites in a variety of assays, but the mechanism by which APP performs this function is not understood. Here, we report that APP is required for proper neurite outgrowth in a cell autonomous manner, both in vitro and in vivo. Neurons that… CONTINUE READING
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