Secretable human platelet-derived factor V originates from the plasma pool.

  title={Secretable human platelet-derived factor V originates from the plasma pool.},
  author={Rodney M. Camire and Eleanor S. Pollak and Kenneth Kaushansky and Paula B. Tracy},
  volume={92 9},
Factor Va (FVa), derived from plasma or released from stimulated platelets, is the essential protein cofactor of the prothrombinase complex. Plasma-derived factor V (FV) is synthesized by the liver, whereas the source of the platelet-derived cofactor has not been unambiguously identified. Megakaryocytes, platelet precursors, are known to synthesize platelet proteins and to endocytose proteins from plasma (ie, fibrinogen) and then package these proteins into alpha-granules. To determine which… CONTINUE READING


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