Secondary transporters of the 2HCT family contain two homologous domains with inverted membrane topology and trans re-entrant loops.

@article{Lolkema2005SecondaryTO,
  title={Secondary transporters of the 2HCT family contain two homologous domains with inverted membrane topology and trans re-entrant loops.},
  author={Juke S. Lolkema and Iwona Sobczak and Dirk Jan Slotboom},
  journal={The FEBS journal},
  year={2005},
  volume={272 9},
  pages={2334-44}
}
The 2-hydroxycarboxylate transporter (2HCT) family of secondary transporters belongs to a much larger structural class of secondary transporters termed ST3 which contains about 2000 transporters in 32 families. The transporters of the 2HCT family are among the best studied in the class. Here we detect weak sequence similarity between the N- and C-terminal halves of the proteins using a sensitive method which uses a database containing the N- and C-terminal halves of all the sequences in ST3 and… CONTINUE READING

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