Secondary sugar binding site identified for LecA lectin from Pseudomonas aeruginosa.

@article{Blanchard2014SecondarySB,
  title={Secondary sugar binding site identified for LecA lectin from Pseudomonas aeruginosa.},
  author={Bertrand Blanchard and Anne Imberty and Annabelle Varrot},
  journal={Proteins},
  year={2014},
  volume={82 6},
  pages={1060-5}
}
The galactose-specific lectin LecA from Pseudomonas aeruginosa is a target for the development of new anti-infectious compounds. Sugar based molecules with anti-adhesive properties present great potential in the fight against bacterial infection and biofilm formation. LecA is specific for oligosaccharides with terminal α-galactoside residues and displays strong affinity for melibiose (αGal1-6Glc) with a Kd of 38.8 µM. The crystal structure of LecA/melibiose complex shows classical calcium… CONTINUE READING
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