Secondary structure and hybridization accessibility of hepatitis C virus 3'-terminal sequences.

@article{Smith2002SecondarySA,
  title={Secondary structure and hybridization accessibility of hepatitis C virus 3'-terminal sequences.},
  author={Robert M.M. Smith and Cherie M. Walton and Catherine H. Wu and George Yung-Hsing Wu},
  journal={Journal of virology},
  year={2002},
  volume={76 19},
  pages={9563-74}
}
The 3'-terminal sequences of hepatitis C virus (HCV) positive- and negative-strand RNAs contribute cis-acting functions essential for viral replication. The secondary structure and protein-binding properties of these highly conserved regions are of interest not only for the further elucidation of HCV molecular biology, but also for the design of antisense therapeutic constructs. The RNA structure of the positive-strand 3' untranslated region has been shown previously to influence binding by… CONTINUE READING

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