Secondary structural analysis of the carboxyl-terminal domain from different connexin isoforms.

@article{Spagnol2016SecondarySA,
  title={Secondary structural analysis of the carboxyl-terminal domain from different connexin isoforms.},
  author={Ga{\"e}lle Spagnol and Mona H Al-mugotir and Jennifer L. Kopanic and Sydney J. Zach and Hanjun Li and Andrew J. Trease and Kelly L. Stauch and Rosslyn Grosely and Matthew Cervantes and Paul L Sorgen},
  journal={Biopolymers},
  year={2016},
  volume={105 3},
  pages={
          143-62
        }
}
The connexin carboxyl-terminal (CxCT) domain plays a role in the trafficking, localization, and turnover of gap junction channels, as well as the level of gap junction intercellular communication via numerous post-translational modifications and protein-protein interactions. As a key player in the regulation of gap junctions, the CT presents itself as a target for manipulation intended to modify function. Specific to intrinsically disordered proteins, identifying residues whose secondary… CONTINUE READING