Secondary resistance to tolvaptan in two patients with SIAD due to small cell lung cancer


Sir, Syndrome of inappropriate antidiuresis (SIAD) is characterized by euvolaemic hyponatraemia due to the antidiuretic effects of inappropriate elevation of plasma vasopressin (pAVP, also referred to as antidiuretic hormone (ADH)). Randomized controlled trials report a good response to tolvaptan-induced vasopressin receptor blockade, with reversal of… (More)
DOI: 10.1007/s00228-017-2363-7


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