Secondary progressive multiple sclerosis: current knowledge and future challenges

  title={Secondary progressive multiple sclerosis: current knowledge and future challenges},
  author={M. Rovaris and C. Confavreux and R. Furlan and L. Kappos and M. Filippi},
  journal={The Lancet Neurology},
  • M. Rovaris, C. Confavreux, +2 authors M. Filippi
  • Published 2006
  • Medicine
  • The Lancet Neurology
  • The secondary progressive phase of multiple sclerosis (MS), which is characterised by a steady accrual of fixed disability after an initial relapsing remitting course, is not clearly understood. Although there is no consensus on the mechanisms underlying such a transition to the progressive phase, epidemiological and neuroimaging studies indicate that it is probably driven by the high prevalence of neurodegenerative compared with inflammatory pathological changes. This notion is lent support by… CONTINUE READING
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