Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.

  title={Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.},
  author={S. Wong and Hsun-Shuo Chang and G. Wang and M. Chiang and H. Huang and C. Chen and Shiow-Chwen Tsai and Chu-Hung Lin and I. Chen},
  journal={Journal of natural products},
  volume={74 12},
  • S. Wong, Hsun-Shuo Chang, +6 authors I. Chen
  • Published 2011
  • Chemistry, Medicine
  • Journal of natural products
  • Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new β-carboline alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds. The structures of 1-6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC₅₀ values of 18… CONTINUE READING
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