Secondary metabolites from Ganoderma.

  title={Secondary metabolites from Ganoderma.},
  author={Sabulal Baby and Anil John Johnson and Balaji Govindan},
Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review
This review summarizes the research progress of some promising natural products and their pharmacological activities of Ganoderma, which has been used as a medicine to treat diseases for more than 2000 years, and its traditional uses.
Ganoderma carnosum and Ganoderma pfeifferi: Metal concentration, phenolic content, and biological activity
This study comprises detailed chemical analysis of two Ganoderma species growing wild in Turkey, G. pfeifferi and G. carnosum, that have strong potential to be used for medicinal purposes.
Secondary Metabolites from Higher Fungi.
This chapter gives a comprehensive overview of the secondary metabolites from higher fungi, with 765 references highlighting the isolation, structure elucidation, biological activities, chemical syntheses, and biosynthesis of pigments, nitrogen-containing compounds, and terpenoids from mushrooms.
Biosynthesis of a novel ganoderic acid by expressing CYP genes from Ganoderma lucidum in Saccharomyces cerevisiae.
Another P450 gene responsible for GA's post-modification was discovered and identified, resulting in the formation of a new GA 3,28-dihydroxy-lanosta-8,24-dien-26-oic acid (DHLDOA) by the engineered yeast, whose chemical structure was confirmed by UPLC-APCI-HRMS and NMR.
Unusual constituents from the medicinal mushroom Ganoderma lingzhi
Extensive studies have revealed that triterpenoids, meroterpenoids, and polysaccharides are the main constituents of the well-known traditional Chinese medicinal mushroom Ganoderma. In this study, we


Isolation and bioactivity evaluation of terpenoids from the medicinal fungus Ganoderma sinense.
Eight new lanostane triterpenoids and a new sesquiterpenoid, ganosinensine, together with eleven known triter penoids, were isolated from the fruiting bodies of the fungus Ganoderma sinense and showed cytotoxic activity and induction ability of hPXR-mediated CYP3A4 expression.
Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells.
Six new highly oxygenated lanostane-type triterpenes were isolated from the spores of Ganoderma lucidum, together with known ganolucidic acid D and ganoderic acid C2, and the cytotoxicity of the compounds was carried out in vitro against Meth-A and LLC tumor cell lines.
Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions.
  • M. Shiao
  • Chemistry, Biology
    Chemical record
  • 2003
The interaction of Ganoderma triterpenoids with human platelets in the induction of aggregation and inhibition of agonist-induced aggregation and signal transduction has been elucidated and reduction of cellular mevalonate content to a stage in which cholesterol synthesis is strongly inhibited and cell growth is marginally arrested sensitizes hepatoma cells to the oxygenated triter penoids.
Effect of 26-Oxygenosterols from Ganoderma lucidum and Their Activity as Cholesterol Synthesis Inhibitors
It is demonstrated that the lanosterol 14α-demethylase, which converts 24,25-dihydrolanosterol to cholesterol, can be inhibited by the 26-oxygenosterols from G. lucidum, which could lead to novel therapeutic agents that lower blood cholesterol.
Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease.
Two new lanostane-type triterpenes, lucidumol A and ganoderic acid beta, were isolated from the spores of Ganoderma (G.) lucidum and showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM.
Aldose reductase inhibitors from the fruiting bodies of Ganoderma applanatum.
The isolation and characterization of rat lens aldose reductase (RLAR) inhibitors from the fruiting bodies of Ganoderma applanatum were conducted. Among the extracts and fractions from G. applanatum
A new ganoderic acid from Ganoderma lucidum mycelia
The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data as 3α,15α,22-triacetoxy-7α-ethoxy-5α-lanost-8,24E-dien-26-oic acid.
Anticomplement activity of terpenoids from the spores of Ganoderma lucidum.
A new lanostane-type terpenoid, lucidenic acid SP1 (1), was isolated from a CHCl(3)-soluble fraction of Ganoderma lucidum spores together with four other known compounds together with a strong anticomplement activity against the classical pathway (CP) of the complement system.
New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells.
Three new lanostante-type triterpene aldehydes, named lucialdehydes A-C (1-3), were isolated from the fruiting bodies of Ganoderma lucidum and showed cytotoxic effects on tested tumor cells.