Secondary metabolic gene cluster silencing in Aspergillus nidulans.

  title={Secondary metabolic gene cluster silencing in Aspergillus nidulans.},
  author={Jin Woo Bok and Daan Noordermeer and Shubha P. Kale and Nancy P Keller},
  journal={Molecular microbiology},
  volume={61 6},
In contrast to most primary metabolism genes, the genes involved in secondary metabolism and certain nutrient utilization pathways are clustered in fungi. Recently a nuclear protein, LaeA, was found to be required for the transcription of several secondary metabolite gene clusters in Aspergillus nidulans. Here we show that LaeA regulation does not extend to nutrient utilization or the spoC1 sporulation clusters. One of the secondary metabolite clusters regulated by LaeA contains the positive… CONTINUE READING
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