Secondary measles vaccine failures identified by measurement of IgG avidity: high occurrence among teenagers vaccinated at a young age.

@article{Paunio2000SecondaryMV,
  title={Secondary measles vaccine failures identified by measurement of IgG avidity: high occurrence among teenagers vaccinated at a young age.},
  author={Mikko Paunio and Klaus Hedman and Irja Davidkin and Martti Valle and Olli Heinonen and Pauli Leinikki and Aimo Salmi and Heikki Peltola},
  journal={Epidemiology and infection},
  year={2000},
  volume={124 2},
  pages={263-71}
}
Failure to seroconvert (primary vaccine failure) is believed to be the principal reason (approx. > 95%) why some vaccinees remain susceptible to measles and is often attributed to the persistence of maternal antibodies in children vaccinated at a young age. Avidity testing is able to separate primary from secondary vaccine failures (waning and/or incomplete immunity), but has not been utilized in measles epidemiology. Low-avidity (LA) and high-avidity (HA) virus-specific IgG antibodies indicate… CONTINUE READING
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