Secondary lymphoid tissue chemokine mediates T cell-dependent antitumor responses in vivo.

@article{Sharma2000SecondaryLT,
  title={Secondary lymphoid tissue chemokine mediates T cell-dependent antitumor responses in vivo.},
  author={Sherven P Sharma and Marina Stolina and Jie Luo and Robert M. Strieter and Marie Burdick and Li Xin Zhu and Raj Kumar Batra and Steven Dubinett},
  journal={Journal of immunology},
  year={2000},
  volume={164 9},
  pages={
          4558-63
        }
}
Secondary lymphoid tissue chemokine (SLC, also referred to as Exodus 2 or 6Ckine) is a recently identified high endothelial-derived CC chemokine. The ability of SLC to chemoattract both Th1 lymphocytes and dendritic cells formed the rationale to evaluate this chemokine in cancer immunotherapy. Intratumoral injection of recombinant SLC evidenced potent antitumor responses and led to complete tumor eradication in 40% of treated mice. SLC-mediated antitumor responses were lymphocyte dependent as… CONTINUE READING
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