Secondary integrase resistance mutations found in HIV-1 minority quasispecies in integrase therapy-naive patients have little or no effect on susceptibility to integrase inhibitors.

@article{CeccheriniSilberstein2010SecondaryIR,
  title={Secondary integrase resistance mutations found in HIV-1 minority quasispecies in integrase therapy-naive patients have little or no effect on susceptibility to integrase inhibitors.},
  author={Francesca Ceccherini-Silberstein and Kurt Van Baelen and Daniele Armenia and Maria Trignetti and Evelien Rondelez and Lavinia Fabeni and Fernanda Scopelliti and Michela Pollicita and Liesbeth Van Wesenbeeck and Veerle Van Eygen and Luca Dori and Loredana Sarmati and Stefano Aquaro and Guido Palamara and Massimo Andreoni and Lieven J. Stuyver and Carlo Federico Perno},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 9},
  pages={3938-48}
}
The goal of this study was to explore the presence of integrase strand transfer inhibitor (InSTI) resistance mutations in HIV-1 quasispecies present in InSTI-naïve patients and to evaluate their in vitro effects on phenotypic susceptibility to InSTIs and their replication capacities. The RT-RNase H-IN region was PCR amplified from plasma viral RNA obtained from 49 HIV-1 subtype B-infected patients (21 drug naïve and 28 failing highly active antiretroviral therapy [HAART] not containing InSTIs… CONTINUE READING

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