Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation.

@article{Jones2007SecondaryHI,
  title={Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation.},
  author={Toni L. Jones and Adam Lustig and Linda S. Sorkin},
  journal={Anesthesia and analgesia},
  year={2007},
  volume={105 6},
  pages={
          1650-6, table of contents
        }
}
BACKGROUND Spinally administered non-N-methyl-D-aspartate (NMDA), but not NMDA, receptor antagonists block primary (1 degree) and secondary (2 degrees) mechanical hyperalgesia and spontaneous pain after plantar incision. Hyperalgesia after thermal stimulation is also mediated by non-NMDA, but not NMDA, receptors. Although previous pain behavior studies in the thermal stimulus model demonstrated distinct protein kinase involvement downstream from spinal non-NMDA receptor activation, protein… CONTINUE READING

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