Secondary gliosarcoma with extra-cranial metastases: a report and review of the literature.


OBJECTIVE To describe a unique case of secondary gliosarcoma (SGS) with widespread extra-cranial metastases that developed more than 5 years after the initial diagnosis of glioblastoma multiforme (GBM). This interval is the longest among the cases reported to date. METHODS A PUBMED search using the key words "secondary gliosarcoma" and "extra-cranial metastases" was performed followed by a review of cited literature. RESULTS Including our report, we found 44 cases of SGS, of which only 5 developed extra-cranial metastases. CONCLUSION SGS with extra-cranial metastases is extremely rare. Of previously reported cases, the longest survival was 2 months after the diagnosis of SGS. The present case had a survival of 6.5 months. Our case highlights the importance of screening for extra-cranial metastases in SGS. The optimal treatment of SGS is not known and strategies based on GBM and sarcoma treatments have been employed with limited success. A combination of treatment modalities may extend survival as in the present report; however the prognosis remains poor.

DOI: 10.1016/j.clineuro.2012.06.017

Cite this paper

@article{Dawar2013SecondaryGW, title={Secondary gliosarcoma with extra-cranial metastases: a report and review of the literature.}, author={Richa Dawar and Andrew J Fabiano and Jingxin Qiu and Nikhil I. Khushalani}, journal={Clinical neurology and neurosurgery}, year={2013}, volume={115 4}, pages={375-80} }