Secondary failure to treatment with oral antidiabetic agents in non-insulin-dependent diabetes.

@article{Groop1986SecondaryFT,
  title={Secondary failure to treatment with oral antidiabetic agents in non-insulin-dependent diabetes.},
  author={Leif Groop and R. Olavi Pelkonen and Saija A. Koskimies and Gian Franco Bottazzo and Deborah Doniach},
  journal={Diabetes care},
  year={1986},
  volume={9 2},
  pages={129-33}
}
To study the etiopathogenesis of secondary drug failure to treatment with oral antidiabetic agents in patients with non-insulin-dependent diabetes (NIDD) we compared 60 "nonresponders" with 60 "responders" to treatment with oral drugs. Secondary drug failure was defined as mean diurnal blood glucose greater than 12 mmol/L after an initial good response of greater than or equal to 2 yr. The nonresponders were characterized by 50% lower C-peptide concentrations than the responders (P less than 0… CONTINUE READING
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