Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.

@article{Yamaguchi1991SecondaryDO,
  title={Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.},
  author={Hiroki Yamaguchi and Yoichi Nakazato and M Shoji and Koichi Okamoto and Yasuo Ihara and Mitsunori Morimatsu and Shunsaku Hirai},
  journal={The American journal of pathology},
  year={1991},
  volume={138 3},
  pages={699-705}
}
The hippocampal areas of 34 autopsy specimen brains from aged demented and nondemented subjects were examined using double staining of Bodian and beta protein. In 18 cases (75.5 +/- 7.4 years old), none of the extracellular neurofibrillary tangles (E-NFTs) were immunoreactive with beta protein. In 16 cases (82.9 +/- 5.4 years old), the minority of E-NFTs were immunoreactive with beta-protein antiserum. These beta-immunoreactive E-NFTs frequently appeared in the areas having senile plaques… CONTINUE READING
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