Secondary chromosome changes in mantle cell lymphoma: cytogenetic and fluorescence in situ hybridization studies.

@article{Bigoni2001SecondaryCC,
  title={Secondary chromosome changes in mantle cell lymphoma: cytogenetic and fluorescence in situ hybridization studies.},
  author={Renato Bigoni and Antonio Cuneo and Raffaella Milani and M G Roberti and Antonella Bardi and G M Rigolin and Francesco Cavazzini and Paola De Agostini and Gianluigi Castoldi},
  journal={Leukemia & lymphoma},
  year={2001},
  volume={40 5-6},
  pages={581-90}
}
To better define the incidence and nature of secondary chromosome anomalies in mantle cell lymphoma (MCL) carrying the t(11:14)/BCL1 rearrangement, cytogenetic and fluorescence in situ hybridization studies (FISH) were performed in 42 patients (39 classical histology, 3 blastoid variant), using 6q21, 9p21/p16, 13q14, 17p13/p53 and chromosome-12-specific probes. Karyotypes from 89 cases published in 5 recent series including patients diagnosed in a homogeneous fashion were reviewed. In our… CONTINUE READING

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