Secondary carnitine deficiency in handicapped patients receiving valproic acid and/or elemental diet.

@article{Igarashi1990SecondaryCD,
  title={Secondary carnitine deficiency in handicapped patients receiving valproic acid and/or elemental diet.},
  author={Naomi Igarashi and Toshihide Sato and S Kyouya},
  journal={Acta paediatrica Japonica : Overseas edition},
  year={1990},
  volume={32 2},
  pages={
          139-45
        }
}
We examined serum-free carnitine (SFC) concentrations and serum acylcarnitine (SAC)/SFC ratios in 40 severely handicapped patients, aged 2 to 36 years, and 69 age-matched control subjects. SFC levels in the patients treated with valproic acid (VPA) and/or receiving carnitine-deficient elemental diets (ED) were significantly lower, and their SAC/SFC ratios were significantly higher than in the other patients or in control subjects. There were 6 patients whose SFC levels were less than the -2SD… CONTINUE READING
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