Secondary adrenal insufficiency after intrathecal steroid administration.

  title={Secondary adrenal insufficiency after intrathecal steroid administration.},
  author={B Chernow and R A Vigersky and J T O'Brian and Linares Georges},
  journal={Journal of neurosurgery},
  volume={56 4},
A 38-year-old man developed secondary adrenal insufficiency as a consequence of intrathecal methylprednisolone administration. Evidence in support of this diagnosis included an absent plasma cortisol response to insulin-induced hypoglycemia, an inadequate adrenal response to exogenous corticotropin stimulation, a typical delayed response to prolonged corticotropin infusion over 3 days, and the findings of an elevated level of prednisolone in the cerebrospinal fluid a full 2 months after its… CONTINUE READING