Secondary Structure of Vertebrate Telomerase RNA

@article{Chen2000SecondarySO,
  title={Secondary Structure of Vertebrate Telomerase RNA},
  author={Jiunn-Liang Chen and M. Blasco and C. Greider},
  journal={Cell},
  year={2000},
  volume={100},
  pages={503-514}
}
Telomerase is a ribonucleoprotein enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The essential RNA component of telomerase provides the template for telomeric repeat synthesis. To determine the secondary structure of vertebrate telomerase RNA, 32 new telomerase RNA genes were cloned and sequenced from a variety of vertebrate species including 18 mammals, 2 birds, 1 reptile, 7 amphibians, and 4 fishes. Using phylogenetic comparative analysis, we… Expand
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