Secondary Metabolites of Plants from the Genus Chloranthus: Chemistry and Biological Activities

  title={Secondary Metabolites of Plants from the Genus Chloranthus: Chemistry and Biological Activities},
  author={An-ran Wang and Hongchuan Song and Hongmei An and Qian Huang and Xie Luo and Jinyan Dong},
  journal={Chemistry \& Biodiversity},
Chloranthus, a genus of the family Chloranthaceae, which is mainly distributed in eastern and southern Asia, has been used in Chinese folk medicine due to its antitumor, antifungal, and anti‐inflammatory activities. This review compiles the research on isolation, structure elucidation, structural diversity, and bioactivities of Chloranthus secondary metabolites reported between 2007 and 2013. The metabolites listed encompass 82 sesquiterpenoids, 50 dimeric sesquiterpenoids, 15 diterpenoids, one… 

Antioxidant Potential of Chloranthus erectus (Chloranthaceae) from various solvents extract

Chloranthus erectus is a herbaceous plant that has been used as a medicinal plant in several regions such as China and Southeast Asia. Although it possesses valuable medicinal properties, till now

Two new polyhydroxysterols produced by Fusarium solani, an endophytic fungus from Chloranthus multistachys

Two new compounds have been isolated from the culture broth of the strain CL39 and are found to belong to the polyhydroxylated steroids with a hydroxyl at C-2 instead of C-3, a rare structure among the steroids.

Antifungal activity of volatile and non-volatile metabolites of endophytes of Chloranthus elatior Sw.

Agriculture crops that have fungal infections suffer significant economic losses and reduced crop output. Chemical fungicides are used to tackle the problem, although this has additional detrimental

Constituents from Chloranthus multistachys and their cytotoxic activities against various human cancer cell lines

Abstract Two new furanoeremophilane sesquiterpenoids, namely, 6,9-dioxo-1α,4α-dihydroxy-furanoeremophilane (1) and 4α,5α-epoxy-6,9-dioxo-1α-hydroxyl-furanoeremophilane (2), and 10 known compounds

Sesquiterpenoids and further diterpenoids from the rare Chloranthaceae plant Chloranthus sessilifolius

Among the isolates, 3α,7β-dihydroxy-ent-abieta-8,11,13-triene exhibited significant anti-neuroinflammatory activity by inhibiting the nitric oxide production in lipopolysaccharide-stimulated murine BV-2 microglial cells, with an IC50 value of 4.3 μM.

Secondary Metabolism in Amaranthus spp. — A Genomic Approach to Understand Its Diversity and Responsiveness to Stress in Marginally Studied Crops with High Agronomic Potential

The role played by this pathway in (a)biotic stress amelioration in plants will be briefly reviewed, followed by an examination of its involvement in the conferral of nutraceutic properties to amaranth plants.

Phytomedicinal aspects of sesquiterpenoid peroxides: Origin, structures and biological activity

Sesquiterpenoid peroxides are a rare group of natural metabolites isolated predominantly from various parts of plants. The biological activity of sesquiterpene peroxides has hardly been studied. This

Anti-neuroinflammatory sesquiterpenoids from Chloranthus henryi

Abstract Hupelactones A (1) and B (2), two new eudesmanolide-type enantiomers of the corresponding compounds, along with four mono- (3–6) and nine dimeric- (7–15) known sesquiterpenoids were isolated

Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi.

  • Y. LeeJ. Moon S. Kim
  • Biology, Medicine
    Journal of agricultural and food chemistry
  • 2009
The disease-control activity of this compound was stronger than the commercially available fungicide chlorothalonil, but weaker than that of dimethomorph, therefore, the compound might serve as an interesting lead to develop effective antifungal agents.

Terpenoids from Chloranthus serratus and their anti-inflammatory activities.

Seven new terpenoids, including two sesquiterpene dimers (1, 2), two norditerpenoids (3, 4), and three sesQUiterpenes (5-7), along with six known sesQuiterpenes dimers and four known sESquiter penes were isolated from the whole plant of Chloranthus serratus, and showed significant anti-inflammatory activities.

Complex sesquiterpenoids with tyrosinase inhibitory activity from the leaves of Chloranthus tianmushanensis.

Investigation of the leaves of Chloranthus tianmushanensis resulted in the isolation and characterization of two new sesquiterpene dimers with a rare 18-membered triester ring and their structures were established by spectroscopic means.

Lignan constituents from Chloranthus japonicus Sieb.

A new coumarinolignan glucoside named yinxiancaoside C, along with five known benzofuran lignans, have been isolated from the whole plant of Chloranthus japonicus Sieb and the cytotoxic activity of the isolated compounds against human hepatoma, ovarian carcinoma, and breast cancer was investigated by MTT method.

Sesquiterpene furan compound CJ-01, a novel chitin synthase 2 inhibitor from Chloranthus japonicus SIEB.

Results indicate that the novel sesquiterpene furan compound CJ-01 is a specific inhibitor of chitin synthase 2 from S. cerevisiae, and showed antifungal activities against various human and phytopathogenic fungi.

New Tyrosinase Inhibitory Sesquiterpenes from Chloranthus henryi

Chemical investigation of the leaves and stems of Chloranthus henryi resulted in the isolation and characterization of two new eudesmane‐type sesquiterpenes, 1 and 2, and two new germacrane‐type

Cadinane and Eudesmane Sesquiterpenoids from Chloranthus henryi

Chemical investigation of the leaves and stems of Chloranthus henryi resulted in the isolation and characterization of the three new cadinane-type sesquiterpenes 1–3 and of the new eudesmane-type