Secondary Metabolism of Dinitrobenzyl Glucuronide Related to Production of Genotoxic Compounds of Dinitrotoluene in Male Wistar Rat

@inproceedings{Mori2000SecondaryMO,
  title={Secondary Metabolism of Dinitrobenzyl Glucuronide Related to Production of Genotoxic Compounds of Dinitrotoluene in Male Wistar Rat},
  author={Masa-aki Mori and Miki Shoji and Michio Sayama and Tokumasa Kondo and Masazumi Inoue and Ken-ichi Kodaira},
  year={2000}
}
Urinary and biliary metabolites of male Wistar rats dosed orally with 2,4-dinitrobenzyl glucuronide (2,4-DNBG) and 2,6-dinitrobenzyl glucuronide (2,6-DNB-G) which are major compounds excreted in bile after administration of carcinogenic 2,4-dinitrotoluene (2,4-DNT) and 2,6-dinitrotoluene (2,6-DNT) were examined by HPLC. The object of this study is to determine whether mutagenic 2,4-dinitrobenzaldehyde (2,4-DNBAl) and genotoxic 2amino-6-nitrobenzyl alcohol (2A6NB) are produced in the secondary… CONTINUE READING

References

Publications referenced by this paper.

Chemical Carcinogenesis and DNA,

  • E. Kriek, J. G. Westra
  • Grover P. (ed.), CRC Press, FL, pp
  • 1979

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