Secondary Ca2+ overload indicates early neuronal injury which precedes staining with viability indicators.

@article{Tymianski1993SecondaryCO,
  title={Secondary Ca2+ overload indicates early neuronal injury which precedes staining with viability indicators.},
  author={M Tymianski and Milton P. Charlton and Peter L. Carlen and Charles Tator},
  journal={Brain research},
  year={1993},
  volume={607 1-2},
  pages={319-23}
}
Spinal neurons, lethally challenged with excitatory amino acids (EAAs) or with high-K+, underwent a biphasic rise in free intracellular calcium concentration ([Ca2+]i). In contrast to the initial rise in [Ca2+]i which recovered, the secondary, irreversible [Ca2+]i increase was unaffected by antagonists of EAA receptors or Ca2+ channels. Also, it correlated highly with cell death, but preceded vital staining with trypan blue and ethidium homodimer, reflecting damaged cellular Ca2+ regulation… CONTINUE READING

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