Second virial coefficient determination of a therapeutic peptide by self-interaction chromatography.

@article{Payne2006SecondVC,
  title={Second virial coefficient determination of a therapeutic peptide by self-interaction chromatography.},
  author={Robert W. Payne and Rajiv Nayar and Ralph Tarantino and Sam Del Terzo and John A. Moschera and Jie Di and David Heilman and Brian Bray and Mark Cornell Manning and Charles S Henry},
  journal={Biopolymers},
  year={2006},
  volume={84 5},
  pages={527-33}
}
Self-interaction of macromolecules has been shown to play an important role in a number of physical processes, including crystallization, solubility, viscosity, and aggregation. Peptide self-interaction is not as well studied as for larger proteins, but should play an equally important role. The osmotic second virial coefficient, B, can be used to quantify peptide and protein self-interaction. B values are typically measured using static light scattering (SLS). Peptides, however, do not scatter… CONTINUE READING