Second trimester two-step trisomy 18 screening using maternal serum markers.

@article{Muller2002SecondTT,
  title={Second trimester two-step trisomy 18 screening using maternal serum markers.},
  author={Françoise Muller and Corinne Sault and Catherine Lemay and Nathalie Roussel-Mizon and François Forestier and Jean-Louis Frendo},
  journal={Prenatal diagnosis},
  year={2002},
  volume={22 7},
  pages={605-8}
}
Trisomy 21 maternal serum marker screening has led to screening for other anomalies, including trisomy 18. Trisomy 18 is generally prenatally diagnosed because of major morphological defects. However, in up to 30% of cases ultrasound signs are unclear, and in most cases diagnosis is performed late in pregnancy. Of the different maternal serum markers, PAPP-A is now considered as the best for trisomy 18 screening. However, pregnancy-associated plasma protein A (PAPP-A) is of value in first… CONTINUE READING