Second-trimester maternal serum immunoreactive inhibin as a marker for fetal Down's syndrome.

@article{Lith1992SecondtrimesterMS,
  title={Second-trimester maternal serum immunoreactive inhibin as a marker for fetal Down's syndrome.},
  author={Jan M. M. van Lith and John J. Pratt and Johan R. Beekhuis and Albert Mantingh},
  journal={Prenatal diagnosis},
  year={1992},
  volume={12 10},
  pages={801-6}
}
We measured immunoreactive inhibin in the maternal serum of 80 pregnancies with a chromosomally normal fetus and ten Down's syndrome pregnancies in the second trimester. The inhibin level in all Down's syndrome pregnancies was above the normal median; the multiple of the normal median (MoM) was 1.9. We found a statistically significant difference between the levels of inhibin in unaffected and affected pregnancies (Kolmogorov-Smirnov test: p < 0.002). Using an arbitrarily chosen cut-off of 2.4… CONTINUE READING