Second-trimester Down syndrome maternal serum screening in twin pregnancies: impact of chorionicity.

@article{Muller2003SecondtrimesterDS,
  title={Second-trimester Down syndrome maternal serum screening in twin pregnancies: impact of chorionicity.},
  author={Françoise Muller and Sophie Dreux and Henry Dupoizat and Serge Uzan and M D Dubin and J E Oury and Bernard Dingeon and Marc Dommergues},
  journal={Prenatal diagnosis},
  year={2003},
  volume={23 4},
  pages={331-5}
}
OBJECTIVE To evaluate the diagnostic value of second-trimester maternal serum screening for Down syndrome in twin pregnancies. METHOD On the basis of a prospective study of second-trimester maternal serum screening, we studied the distribution of alpha-fetoprotein (AFP) and free ss hCG in 3043 twin pregnancies with known outcome. There were 1561 dichorionic and 244 monochorionic pregnancies. The placental type was not available in 1238 cases. We compared 5 screening policies with the same… CONTINUE READING

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