Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress.

@article{Boehm2009SecondMS,
  title={Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress.},
  author={Alexander Boehm and Samuel Steiner and Franziska Zaehringer and Alain Casanova and Fabienne Hamburger and Daniel Ritz and W. Keck and Martin Ackermann and Tilman Schirmer and Urs Jenal},
  journal={Molecular microbiology},
  year={2009},
  volume={72 6},
  pages={1500-16}
}
Biofilms are communities of surface-attached, matrix-embedded microbial cells that can resist antimicrobial chemotherapy and contribute to persistent infections. Using an Escherichia coli biofilm model we found that exposure of bacteria to subinhibitory concentrations of ribosome-targeting antibiotics leads to strong biofilm induction. We present evidence that this effect is elicited by the ribosome in response to translational stress. Biofilm induction involves upregulation of the… CONTINUE READING

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