Second messenger regulation of mRNA for corticotropin-releasing factor.

@article{Majzoub1993SecondMR,
  title={Second messenger regulation of mRNA for corticotropin-releasing factor.},
  author={Joseph A. Majzoub and R. W. Emanuel and Grazyma Adler and Carmen Martinez and Bruce Robinson and Gary A Wittert},
  journal={Ciba Foundation symposium},
  year={1993},
  volume={172},
  pages={
          30-43; discussion 43-58
        }
}
An understanding of how second messengers and their ligands are coupled to CRF gene activation is necessary if we are to understand the regulation of the CRF gene in physiological and pathological states. The protein kinase A, protein kinase C and glucocorticoid second messenger systems mediate most of the regulation of the CRF gene. In in vitro systems, CRF gene expression is stimulated 20-30-fold by activation of either the protein kinase A or the protein kinase C system. Glucocorticoid is… CONTINUE READING
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