Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma lines.

@article{Knox1992SecondmessengerPI,
  title={Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma lines.},
  author={Kirstine A. Knox and Michael Finney and Anne E. Milner and Christopher D Gregory and Michael J. O. Wakelam and Robert H Michell and John Gordon},
  journal={International journal of cancer},
  year={1992},
  volume={52 6},
  pages={
          959-66
        }
}
Spontaneous apoptosis in germinal-centre (GC) B cells can be prevented by treatment with anti-immunoglobulin (Ig). By contrast, susceptible group-I Burkitt lymphoma (BL) cells can be driven to apoptosis by anti-Ig. The second-messenger pathways involved in the regulation of apoptosis in GC B lymphocytes and in BL cell lines were studied using pharmacological agonists or inhibitors of intracellular calcium ([Ca2+]i) and protein kinase C (PKC). Anti-Ig was found to mobilize Ca2+ in group-I cells… CONTINUE READING

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