Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR)

@article{Guse2005SecondMF,
  title={Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR)},
  author={Andreas H. Guse},
  journal={The FEBS Journal},
  year={2005},
  volume={272}
}
  • A. Guse
  • Published 1 September 2005
  • Biology, Chemistry
  • The FEBS Journal
Cyclic ADP‐ribose (cADPR) is a Ca2+ mobilizing second messenger found in various cell types, tissues and organisms. Receptor‐mediated formation of cADPR may proceed via transmembrane shuttling of the substrate NAD and involvement of the ectoenzyme CD38, or via so far unidentified ADP‐ribosyl cyclases located within the cytosol or in internal membranes. cADPR activates intracellular Ca2+ release via type 2 and 3 ryanodine receptors. The exact molecular mechanism, however, remains to be… 
8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist
TLDR
8-Br-N1-cIDPR appears to be the first cADPR agonist affecting Ca2+ release and secondary Ca2- entry, but without effect on TRPM2.
Regulation of calcium signalling by adenine-based second messengers.
TLDR
This work has shown that activation of specific plasma membrane receptors is connected to cADPR formation in many cell types and tissues, and receptor-mediated formation of NAADP and ADPR has been shown only in a few selected cellular systems.
cADPR stimulates SERCA activity in Xenopus oocytes.
Regulation of the renal microcirculation by ryanodine receptors and calcium-induced calcium release
TLDR
RyR and CICR are important regulations of Ca2+ signaling and contractile tone of renal resistance arterioles in healthy kidneys and the role of this novel-signaling pathway in pathophysiological mechanisms awaits investigation.
Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs
TLDR
The synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca2+-releasing secondary messenger that was firstly isolated from sea urchin eggs extracts, revealed to be the only one provided with Ca 2+ release properties.
Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5′-diphosphate ribose”
TLDR
Results highlight the key role of the “northern” ribose in the interaction of cADPR with CD38 and suggest that 8-Br-L-cIDPR potentially binds non-productively in an upside-down fashion.
New Molecular Mechanisms on the Activation of TRPM2 Channels by Oxidative Stress and ADP-Ribose
TLDR
The effects of various inhibitors such as flufenamic acid and PARP inhibitors on ADPR, NAD+ and H2O2-induced TRPM2 currents are reviewed, and inhibitor roles of antioxidants are summarized.
A Calcium Influx Pathway Regulated Separately by Oxidative Stress and ADP-Ribose in TRPM2 Channels: Single Channel Events
TLDR
Support for a calcium influx pathway regulated separately by oxidative stress and ADPR in TRPM2 channels in transfected cells is observed and H2O2-induced a single-channel conductance in the current study; the first time that this has been resolved in CHO.
Diadenosine Homodinucleotide Products of ADP-ribosyl Cyclases Behave as Modulators of the Purinergic Receptor P2X7*
TLDR
Results identify P18 as a new P2X7 antagonist, potentially useful in the treatment of CMT1A, and triggers a slow and sustained influx of extracellular Ca2+ through the opening of the purinergic receptor/channel P2 X7.
Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers
TLDR
It is shown here that, after cyclisation, there are two possible macrocyclic product conformers that may be formed, depending on whether cyclisation occurs to the “right” or the "left” of the adenine base (as viewed along the H-8 → C-8 base axis).
...
...

References

SHOWING 1-10 OF 75 REFERENCES
Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR).
  • A. Guse
  • Biology, Chemistry
    Current medicinal chemistry
  • 2004
TLDR
The cADPR signaling pathway may become a valuable target for pharmaceutical intervention since Ca2+ ions are regulators of many diverse cell functions, e.g. muscle contraction, secretion of neurotransmitters, hormones and enzymes, fertilization of oocytes, and lymphocyte activation and proliferation.
Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR).
  • A. Guse
  • Biology
    Current molecular medicine
  • 2004
TLDR
The role of cADPR in a cell system studied in detail, human T-lymphocytes, and the mechanisms of c ADPR-mediated Ca2+ release and Ca2+.
Cyclic ADP ribose activation of the ryanodine receptor is mediated by calmodulin
TLDR
It is reported that sea urchin egg microsomes purified by Percoll gradients lose sensitivity to cADPR, but the response can be restored by a soluble protein in the supernatant, indicating that it is calmodulin.
Autocrine and Paracrine Calcium Signaling by the CD38/NAD+/Cyclic ADP‐Ribose System
TLDR
This paradox is solved by identifying some NAD+ and cADPR transmembrane transporters, whose interplay mediates a hitherto‐unrecognized subcellular and intercellular trafficking of nucleotides that enhances intracellular Ca2+ ([Ca2+]i).
Structure and enzymology of ADP-ribosyl cyclases: conserved enzymes that produce multiple calcium mobilizing metabolites.
Cyclic ADP-ribose is an important calcium mobilizing metabolite produced by the ADP-ribosyl cyclase (cyclases) family of enzymes. Three evolutionarily conserved ADP-ribosyl cyclase superfamily
Cyclic GMP-dependent and -independent Effects on the Synthesis of the Calcium Messengers Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate*
TLDR
The complex metabolic pathways characterized in this study indicate that there may be a multitude of regulatory mechanisms for controlling the endogenous concentrations of cADPR and NAADP.
Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity.
TLDR
Three novel analogues modified in the "northern" ribose (ribose linked to N1 of adenine) of the Ca(2+) mobilizing second messenger cyclic adenosine diphosphoribose were synthesized and spectroscopically characterized, and the pK(a) values for the 6-amino/imino transition were determined in two cases.
Fluorescent analogs of cyclic ADP-ribose: synthesis, spectral characterization, and use.
TLDR
It is shown that ADP-ribosyl cyclase catalyzes the cyclization of not only NAD+ but also several of its analogs with various purine bases (guanine, hypoxanthine, or xanthine) substituting for adenine, which is novel since the site of cyclization is at the N1-position for cADPR as determined by X-ray crystallography.
...
...