Second meiotic spindle integrity requires MEK/MAP kinase activity in mouse eggs.

@article{Petrunewich2009SecondMS,
  title={Second meiotic spindle integrity requires MEK/MAP kinase activity in mouse eggs.},
  author={Mary Ann F Petrunewich and James Robert Trimarchi and Amy Katherine Lindsey Hanlan and Magnus D. Hammer and Jay M Baltz},
  journal={The Journal of reproduction and development},
  year={2009},
  volume={55 1},
  pages={
          30-8
        }
}
ERK-type MAP kinase activity is required for normal first meiotic (MI) metaphase spindle dynamics and first polar body formation at the MI/MII transition, and for MII arrest until egg activation. MEK and MAPK, however, remain active until meiosis is completed and pronuclei form, but whether MEK/MAPK activity affects MII spindle function during egg activation has been unknown. Polarized light microscopy revealed that the MII spindle rapidly (within approximately 15 min) lost birefringence upon… CONTINUE READING

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